Found 12 matching trials
Debio 1143-201 Dose-finding and Efficacy Phase I/II Trial NA The use of multiple drugs in a single clinical trial or as a therapeutic st...
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Centre Hospitalier de Bretagne Sud - HÔPITAL DU SCORFF
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Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX) PHASE1 The purpose of this study is to evaluate the tolerability and safety of Xev...
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Mount Sinai Comprehensive Cancer Center
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Study to Assess Xevinapant in Preoperative Subjects With Recurrent High-Grade Glioma (rHGG) PHASE1 Researchers will investigate the ability of Xevinapant to cross the blood-b...
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Multiple Locations
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Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION) PHASE3 The purpose of this study is to demonstrate the superior efficacy of Xevina...
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University of Alabama at Birmingham - Dept of Radiation Oncology
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PK Study of Xevinapant (Debio 1143) in Healthy East Asian Participants PHASE1 The purpose of this study was to evaluate the pharmacokinetics (PK) of Xevi...
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Labcorp Clinical Research Unit Limited
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A Dose-Finding Study of the Second Mitochondrial Activator of Caspases (SMAC) Mimetic Debio 1143 When Given in Combination With Avelumab to Participants With Advanced Solid Malignancies and to Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Platinum-Based Therapy PHASE1 The study is primarily designed to assess the safety and tolerability of es...
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Cross Cancer Center Dept Medicine
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Dose Escalation Study of Safety and Tolerability of AT-406 in Patients With Advanced Solid Tumors and Lymphomas PHASE1 The purpose of this study is to determine the safety profile and the maximu...
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University of Michigan Cancer Center
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Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer PHASE2 This phase II trial compares the effect of usual radiation therapy with cis...
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Multiple Locations
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Debio 1143 in Combination With Carboplatin and Paclitaxel in Patient With Advanced Solid Malignancies PHASE1 This is a two-part trial in patients with squamous non-small cell lung canc...
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Centre Georges François Leclerc
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Pembrolizumab In Combination With Debio 1143 In Pancreatic and Colorectal Advanced/Metastatic Adenocarcinoma PHASE1 This trial is a Phase I study to be conducted in patients with non-MSI-high...
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Centre Léon Bérard
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